The Matrix-Driven Delivery (MDD) System
Can the pellets be used in humans?
No, our pellets are for explicit use in laboratory animals only.
How does the MDD system work?
The MDD Pellet System works by the double process of erosion
of the pellet and diffusion of the active product.
What are the pellets made of?
The pellet is made of a matrix fused with an active
product. The ingredients are: cholesterol, cellulose,
lactose, phosphates and stearates.
Can I get special shaped pellets?
Yes, you can get any shape, in any form.
Is the Matrix the same for all products?
No, we use more than 1,700 different types of matrixes.
- Can you have more than one active product in the same
Yes, pellets can be made with more than one active product
depending on their chemical compatibility.
- Are the pellets immunogenic?
No, our pellets are biologically inert and do not affect the
- Can I break a large pellet into smaller fragments?
No, the pellets can not be broken because the active product is
concentrated in the center of the pellet for steady release.
- How should the pellets be stored?
The pellets vary in storage requirements depending on the active
product so be sure to check the bottle for
temperature and light requirements and avoid humidity.
- How long are the pellets good for?
If the products are stored according to the instructions on the
bottle they are guaranteed for 3 years from the date you
- How do I sterilize the pellets if I have doubt?
We suggest two ways:
1) Nitric Oxide gas sterilization
2) UV light and blower in a laminar hood
Implantation and Removal
How do I implant the pellet?
For pellets up to 5mg we recommend using one of our
precision trochars. Detailed
instructions for implantation using the trochar or for
pellets larger than 5mg can be found on our website,
Also, if you are implanting both placebo pellets and pellets
containing the active product concurrently and you are using
a trochar, implant the placebos first to avoid any residual
active product contaminating the placebo pellets.
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Should I sterilize the skin with alcohol
No, the pellets are designed to activate when they come
in contact with fluids inside the body. Any
exogenous fluids may alter the release rates of the pellets.
Are the pellets sterile?
Yes, even if a pellet falls on the bench it is still sterile.
What is a trochar?
It is a reusable, stainless steel needle with an obturator
that can be used for easy pellet implantation.
Must I sterilize the trochar after every implantation?
The trochar does not need to be sterilized after each
implantation. If you do decide to sterilize the
trochar with alcohol remember not to use it again until it
is fully dry. Any exogenous fluids may alter the
release rates of the pellets.
How do I sterilize a trochar?
We recommend using an autoclave.
Where should I implant the pellets?
Our pellets are mainly used subcutaneously between the skin
and muscle tissue.
The ideal implantation location for mice or rats is the
lateral side of the neck between the ear and shoulder. However a location with the
most space between the skin and muscle and the animal can
not play with the pellet is sufficient.
Can the pellets be implanted other than subcutaneously?
Yes, the pellets can be implanted intravenously,
intramuscularly, interparatonialy, in the eye, in the brain,
in bone marrow, in the mammary gland, in the cervix or
Can I implant more than one pellet?
Yes you can. Up to 20 pellets can be implanted
depending on the physical size of the animal.
Are the pellets removable?
Yes, however the pellet cannot be re-implanted after it has
I have noticed after the experiment is over I can still
see the pellet under the skin, do I need to remove it?
No, the remaining matrix has no immunogenic effects and
will be absorbed by the animal.
Animal Reactions to the Pellet
- Why would I observe any edema or swelling around the
Edema could only occur if the pellet is too large for
the animal or the underlying muscle was injured during
implantation. The pellets are sterile and will not
Release Rates and Dosages
- When do the pellets start releasing the active
The active product begins releasing immediately after
- Is this zero order or first order kinetics?
The pellets are zero order kinetics releasing a steady
dose for the pellets designed release time.
- How long will a pellet release a given product?
The pellets release a constant, even amount of active
product for the designed release time of the pellet.
- Are the release and blood levels always the same?
No, blood levels depend on the clearance of the
active product by the host and the half life of
the active product it self.
- How do I check if the release is uniform?
First remove the pellet. Then measure the amount
of active product left in the pellet. By
conclusion we can establish how much active product was
- How do I choose the proper dose
for the pellet?
If you know how much active product you want
released daily use the following formula:
daily dose desired x number of days
= dose for pellet
(example: .01mg x 21 days = .21mg pellet)
2) If you want to know how much active product per day
is release by a given pellet use the following formula:
dose of pellet / number of days =
daily dose released
(example: .21mg pellet / 21 days = .01mg
- What are the smallest and largest dosages available?
The smallest dose is 1µg and the highest dose is
200mg, but we can specially design a smaller or larger
dose to fit your needs.
- What if I don't know exactly what dose to use to
get a desired blood level?
We recommend doing a mini-dose response curve.
- Can I get a pellet that releases beyond 90 days?
Yes you can, but we recommend using multiple pellets
instead. For example if you want 180-day
release pellets use two 90-day release pellets instead. On
day one implant the first pellet and on day 91 implant
the second pellet.
- What constitutes a custom pellet?
We consider custom pellets to be any active product we
do not have listed in our catalog or online regardless
of dose or release time.
- Does your time release technology work with other
active products not listed on your website?
Yes, Our technical staff can apply our patented
techniques to virtually any compound.
- How do I order custom pellets?
You can print out a copy of our
custom pellet form
and fax it to us or you can place an order for
online. Please be as thorough as possible when
completing the forms.
- Do I need to supply you with raw material for
You can if you desire or if possible we can order it for
you and charge you fair market price.